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biolegend 444107 mouse MIF elisa kit代理

  • 更新時(shí)間:  2023-07-26
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  • biolegend 444107 mouse MIF elisa kit代理
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biolegend 444107 mouse MIF elisa kit代理

Kit Contents
 
  • Anti-Mouse MIF Pre-coated 96 well Strip Microplate
  • Mouse MIF Detection Antibody
  • Mouse MIF Standard
  • Avidin-HRP
  • Assay Buffer B
  • Wash Buffer (20X)
  • Substrate Solution F
  • Stop Solution
  • Plate Sealers

biolegend 444107 mouse MIF elisa kit代理

Product Details
 
Application:ELISA
Standard Range:156 - 10,000 pg/mL
Sensitivity:25.28 ± 1.68 pg/mL

Description:

Macrophage migration inhibitory factor (MIF), also known as glycosylation inhibiting factor (GIF), is a pituitary hormone and a macrophage- and T cell-derived cytokine that plays an important role in the endocrine and immune systems. MIF consists of 115 amino acids and has a molecular weight of 12.5 kD. Mouse MIF shares most of its identity with human (90%), rat (99%), and cattle (88%) MIFs, and a moderate percentage of its identity with MIFs from a wide variety of other species. It exists in monomeric, dimeric, and trimeric forms of identical protomers.

MIF is active as a pro-inflammatory regulator and upregulates multiple cytokines that are vital to combating infections in vivo, including tumor-necrosis factor (TNF), interferon-γ (IFN-γ), and interleukin-12 (IL-12). It is known to maintain cell survival and promote pro-inflammatory immune responses. MIF also activates the ERK1/ERK2 signaling pathway, which inhibits the immunosuppressive effects of glucocorticoids. MIF also plays a critical role in superantigen-induced toxic shock. It upregulates several factors that enhance the growth and invasiveness of gram-negative bacteria. MIF can enhance many inflammatory diseases, such as acute respiratory distress syndrome, arthritis, atopic dermatitis, allograft rejection, glomerulonephritis, inflammatory bowel diseases, asthma, and atherosclerosis. Known receptors for MIF include CXCR2, CXCR4, CD44, and CD74.

The LEGEND MAX™ Mouse MIF ELISA kit is a ready-to-use Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with a rat monoclonal anti-mouse MIF antibody. The Detection Antibody is a biotinylated goat polyclonal anti-mouse MIF antibody. This assay is specifically designed to quantify mouse MIF from serum, plasma, cell culture supernatant, and cell lysate. This kit is analytically validated with prepared reagents.

 

上海力敏實(shí)業(yè)有限公司作為biolegend代理,Biolegend公司的試劑主要包括細(xì)胞免疫、細(xì)胞因子、趨化因子、粘附分子等及與癌癥研究、T 調(diào)節(jié)細(xì)胞研究、干細(xì)胞研究、先天免疫研究、細(xì)胞周期分析、凋亡研究及特定修飾類抗體等領(lǐng)域相關(guān)的試劑,用于流式、ELISA、免疫沉淀、WB、免疫熒光、免疫組化、及體內(nèi)體外功能學(xué)試驗(yàn)。其中,Biolegend公司的流式抗體以其具有較寬范圍的熒光選擇及較高的性價(jià)比,為廣大科研工作者所接受!同時(shí),公司配備了一支經(jīng)驗(yàn)豐富的技術(shù)服務(wù)隊(duì)伍,為客戶提供*的配色方案及快速的售后處理服務(wù)!


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